Effectiveness: PASI change from baseline at 12 weeks was 58%. Side Effects: Methotrexate may cause very serious side effects. Some side effects of methotrexate may cause death. You should only take methotrexate to treat life-threatening cancer, or certain other conditions that are very severe and that cannot be treated with other medications. Methotrexate may cause a decrease in the number of blood cells made by your bone marrow. Methotrexate may cause liver damage, especially when it is taken for a long period of time. Methotrexate may cause lung damage. Methotrexate may cause damage to the lining of your mouth, stomach or intestines. Cost: Average cost of a 30-year course of treatment: USD$37,591

Ciclosporine

Effectiveness: PASI change from baseline at 12 weeks was 72%. Side effects: Cyclosporine side effects can be extremely damaging. Due to the fact that cyclosporine acts on the body, it is possible to experience cyclosporine side effects years after using it. It is important to understand the parameters of prescriptions, including possible cyclosporine side effects and potential cyclosporine risks. More common cyclosporine side effects can include high blood pressure, kidney problems, increase in hair growth, and trembling and shaking of hands. More serious cyclosporine side effects that some patients suffer are convulsions, vomiting, fevers, and frequent urge to urinate. Cyclosporine side effects can cause a person to experience feelings of confusion, numbness, discomfort, stomach pain, nervousness, malaise, weight loss. Very serious cyclosporine side effects have included blood in urine, in addition to the development of certain types of cancer. Cost: Average cost of a 30-year course of treatment: Similar to Metotrexate.

Acetriten or Soriatane

Effectiveness: Historically prescribed for skin psoriasis. Plaque psoriasis: PASI change from baseline at 12 weeks was 51,7%. Side effects: Acitretin or Soriatane can cause skin peeling and scaling, hair loss, itching, dry skin, dry mouth, headache, tiredness, impotency, and bleeding gums. Because sun light is able to increase the severity of the skin side effects, sun screen is needed. Acitretin or Soriatane can cause severe birth defects, and there is even some proof that the effect may extend to men who father children.. Cost: Average cost of a 30-year course of treatment: USD$75,113

Taclonex

Taclonex contains a combination of betamethasone and calcipotriene. Betamethasone is a topical corticosteroid

Effectiveness: PASI change from baseline at 4 weeks was 70%. Side effects: dry skin, headache, itching, or mild burning at the application site, acne-like rash; burning, cracking, irritation, redness, or peeling skin, excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; thinning, softening, or discoloration of the skin; or unusual weight gain, especially in the face. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. Cost: Average cost of a 30-year course of treatment: USD$144,000

Biologics

Amevive, Enbrel, Humira, Remicade, Cimzia

Effetiveness: PASI change from baseline was 75% for 29% patients. Side effects: Amevive Side effects include headache, itching, sore throat, dizziness, nausea, and muscle aches. Amevive isn't usually recommended for pregnant or nursing women, children, the elderly, or people with infections. Blood tests are required every two weeks during treatment to monitor white blood cell levels. Enbrel side effects include skin irritation and rashes. It should not be used in people with multiple sclerosis and heart failure Remicade side effects include tuberculosis, invasive fungal infections, and other serious infections have been reported in Remicade patients; some of the infections have been fatal. Humira's side effects include serious and even fatal infections such as tuberculosis, an increased risk of certain types of cancer such as lymphoma, and an increased risk of autoimmune disorders such as a lupus-like syndrome. Raptiva was pulled from the market in April 2009 due to an increased risk of a fatal infection, progressive multifocal leukoencephalopathy, to develop in the brain. Cost: Average cost of a 30-year course of treatment: USD$689,415.

PUVA= UVA + Psoralen - Office

Effetiveness: PASI change from baseline in 12 weeks was 75% for 63% patients. Side effects: Increased risk of skin aging, freckling and skin cancer with long-term treatment Side effects may include nausea, headache, fatigue, burning skin, itching and irregular skin pigmentation. Cost: Average cost of a 30-year course of treatment: USD$155,640

Narrow Band Ultraviolet Light - UVB NB - Office

Efectiveness: Typically 20-25 sessions to clear Long term remission for 90% of patients. Side effets: Phototherapy of skin diseases such as psoriasis is an effective and safe treatment modality. No evidence for an increased skin cancer risk for patients treated with either broadband or narrowband UVB phototherapy was found. Cost: Value of 30-year course of treatment: USD$155,640

Psoriator + High Power

Effetiveness: Use High Power as a detox formula and Psoriator treatment for psoriasis. PASI change from baseline in 3 weeks was 100% for 20% patients, 60% for 75% patients and 0% for 5% patients. PASI change from baseline in 6 weeks was 100% for 20% of 75% patients, 80% for 80% of 75% patients. Cost: Value of 30-year course of treatment: USD$8.000.

Psoriator + High Power + Home UVB NB

Effetiveness: PASI change from baseline in 8 weeks near 100% for 100% patients. Recommended treatment for severe psoriasis: Psoriator for 6 weeks, UVB NB for additional 2 weeks. Cost: Value of 30-year course of treatment: USD$20,000.